Direktor
| Prof. Dr. med. Dr. rer. nat. Klaus Aktories |
 |
| Curriculum Vitae | |
| Office Address | Institute of Experimental and Clinical Pharmacology and Toxicology Albert-Ludwigs-Universität Freiburg Albertstr. 25, Otto-Krayer-Haus D-79104 Freiburg, Germany |
Education |
|
| 1967 | High school examination |
| 1969-1972 | Study of Pharmacy, University of Frankfurt |
| 1971-1977 | Study of Medicine, University of Frankfurt |
Dissertations |
|
| 1977 Dr. med. (MD) | Faculty of Medicine, University of Frankfurt (Mentor Prof. Dr. H.-D. Taubert) |
| 1981 Dr. rer. nat. (Ph. D.) | Faculty of Natural Sciences (Naturwissenschaftl. Gesamtfakultät), University of Heidelberg (Mentor Prof. Dr. G. Schulz) |
Habilitation |
|
| 1983 | Faculty of Theoretical Medicine, University of Heidelberg |
Professional Appointments |
|
| 1978-1984 Research Associate | Department of Pharmacology at the University of Heidelberg (Group of Prof. Dr. G. Schultz) |
| 1984-1985 Research Associate | Department of Psychiatry at the University of Mainz (Director Prof. Dr. O. Benkert) |
| 1985-1989 Associate Professor (C2) | Rudolf-Buchheim-Institute of Pharmacology at the University of Gießen |
| 1989-1991 Associate Professor (C3) | Institute of Pharmacology at the University of Essen |
| 1991-1994 Full Professor (C4) | Institute of Pharmacology and Toxicology at the University of the Saarland |
Present Position |
|
| Since 1995 Full Professor (C4) and Director (Chair) |
Department I of the Institute of Experimental and Clinical Pharmacology and Toxicology at the Albert-Ludwigs-Universität Freiburg |
| 2003 | Coordinator of the Priority Research Program 1150 (Schwerpunktprogramm 1150) of the DFG: “Signalwege zum Zytoskelett und bakterielle Pathogenität” |
Sabbaticals |
|
| 1989 | Institute of Cancer Research, Chester Beatty Laboratories, London, Group of Prof. Dr. A. Hall |
| 1998 | Department of Microbiology and Molecular Genetics, Medical College Wisconsin (Milwaukee), Group of Prof. Dr. J.T. Barbieri |
Honors |
|
|
Julius Friedrich Cohnheim Lecture, Tel Aviv University, 1998 |
|
Membership in Editorial Boards (past and present) |
|
| European Journal of Pharmacology Naunyn-Schmiedeberg’s Archives of Pharmacology Medical Microbiology and Immunology Toxicon Infection and Immunity International Journal of Medical Microbiology |
|
Research topics |
|
| Bacterial protein toxin - Clostridial glucosylating toxins - Pasteurella multocida toxin - ADP-ribosylating toxins - Rho-GTPase activating and inhibiting toxins - Legionella glucosyltransferases Molecular mechanism and structure-function analysis of bacterial protein toxins Bacterial protein toxins as pharmacological tools Signal transduction of GTPases Role of GTPases in neurite outgrowth and pathfinding Signal transduction of the FceRI-receptor |
|
Patents |
|
| De0019802569A1 | Toxikologisch aktive Fragmente des letalen Toxins von Clostridium sordellii und deren Verwendung in Immuntoxinen |
| DE0019735105A1 | Transportsystem zur Einbringung von Proteinen in Zielzellen mit Hilfe eines Fusionsproteins, Nucleinsäurekonstrukte kodierend für die Komponenten des Transportsystems und Arzneimittel, die Komponenten des Transportsystems umfassen |
| EP1452589A1 | ADP-Ribosyltransferase C3cer |