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Prof. Dr. med. Robert Grosse

Robert GrosseCIBSS


Qualifications and history

1992     Research assistant, Georgetown University Medical Center, Washington DC, USA
1997 Internship, St. Mary’s Hospital, Imperial College London, UK
1998 Medical license, MD, Free University Berlin, Benjamin Franklin Campus
1994-99 Doctoral thesis work, Institute of Pharmacology, Free University Berlin
2000 Postdoctoral fellow (ICRF Fellow and EMBO Fellow), London Research Institute (LRI), UK
2004 Emmy Noether Group leader, University of Heidelberg, Medical Faculty
2009 Habilitation and Medical Specialization (Facharzt) in Pharmacology, University of Heidelberg
2009 Full professor and chair, Institute of Pharmacology, University of Marburg, Medical Faculty
2019 Full professor and chair, Institute of Experimental and Clinical Pharmacology and Toxicology, University of Freiburg, Medical Faculty


Honors and Awards

2019     Appointed CIBSS Professor (Centre for Integrative Biological Signalling Studies)
2016 HFSP (Human Frontiers Science Program) lead investigator of program grant
2013 Binder-Innovation Prize
2008 Joachim Siebeneicher Research Prize
2004 Emmy Noether Program


10 Selected Publications

Krippner S, Winkelmeier J, Knerr J, Brandt DT, Virant D, Schwan C, Endesfelder U, Grosse R (2020) Postmitotic expansion of cell nuclei requires nuclear actin filament bundling by α-actinin 4. EMBO Rep, 21, e50758, 1-11
Abstract

Bouhaddou M, Memon D, Meyer B, White KM, Rezelj VV, Correa Marrero M, Polacco BJ, Melnyk JE, Ulferts S, Kaake RM, Batra J, Richards AL, Stevenson E, Gordon DE, Rojc A, Obernier K, Fabius JM, Soucheray M, Miorin L, Moreno E, Koh C, Tran QD, Hardy A, Robinot R, Vallet T, Nilsson-Payant BE, Hernandez-Armenta C, Dunham A, Weigang S, Knerr J, Modak M, Quintero D, Zhou Y, Dugourd A, Valdeolivas A, Patil T, Li Q, Hüttenhain R, Cakir M, Muralidharan M, Kim M, Jang G, Tutuncuoglu B, Hiatt J, Guo JZ, Xu J, Bouhaddou S, Mathy CJP, Gaulton A, Manners EJ, Félix E, Shi Y, Goff M, Lim JK, McBride T, O'Neal MC, Cai Y, Chang JCJ, Broadhurst DJ, Klippsten S, De Wit E, Leach AR, Kortemme T, Shoichet B, Ott M, Saez-Rodriguez J, tenOever BR, Mullins RD, Fischer ER, Kochs G, Grosse R, García-Sastre A, Vignuzzi M, Johnson JR, Shokat KM, Swaney DL, Beltrao P, Krogan NJ (2020) The Global Phosphorylation Landscape of SARS-CoV-2 Infection. Cell, 182, 685-712
Abstract

Wang Y, Sherrard A, Zhao B, Melak M, Trautwein J, Kleinschnitz EM, Tsopoulidis N, Fackler OT, Schwan C, Grosse R (2019) GPCR-induced calcium transients trigger nuclear actin assembly for chromatin dynamics. Nat Commun, 10, 5271, 1-9
Abstract

Baarlink C, Plessner M, Sherrard A, Morita K, Misu S, Virant D, Kleinschnitz EM, Harniman R, Alibhai D, Baumeister S, Miyamoto K, Endesfelder U, Kaidi A, Grosse R (2017) A transient pool of nuclear F-actin at mitotic exit controls chromatin organization. Nat Cell Biol, 19, 1389-99
Abstract

Hinojosa LS, Holst M, Baarlink C, Grosse R (2017) MRTF transcription and Ezrin-dependent plasma membrane blebbing are required for entotic invasion. J Cell Biol, 216, 3087-95
Abstract

Grikscheit K, Frank T, Wang Y, Grosse R (2015) Junctional actin assembly is mediated by Formin-like 2 downstream of Rac1. J Cell Biol, 209, 367-76
Abstract

Wang Y, Arjonen A, Pouwels J, Ta H, Pausch P, Bange G, Engel U, Pan X, Fackler OT, Ivaska J, Grosse R (2015) Formin-like 2 Promotes β1-Integrin Trafficking and Invasive Motility Downstream of PKCα. Dev Cell, 4, 475-83
Abstract

Baarlink C, Wang H, Grosse R (2013) Nuclear actin network assembly by formins regulates the SRF coactivator MAL. Science, 340, 864-7
Abstract

Brandt DT, Baarlink C, Kitzing TM, Kremmer E, Ivaska J, Nollau P, Grosse R (2009) SCAI acts as a suppressor of cancer cell invasion through the transcriptional control of β1-integrin. Nat Cell Biol, 11, 557-68
Abstract

Kitzing TM, Sahadevan AS, Brandt DT, Knieling H, Hannemann S, Fackler OT, Grosshans J, Grosse R (2007) Positive feedback between Dia1, LARG, and RhoA regulates cell morphology and invasion. Genes Dev, 21, 1478-83
Abstract

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