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 Prof. Dr. med. Dr. rer. nat.
 Klaus Aktories
Klaus Aktories
 Curriculum Vitae








 
Office Address Institute of Experimental and Clinical Pharmacology and Toxicology
Albert-Ludwigs-Universität Freiburg
Albertstr. 25, Otto-Krayer-Haus
D-79104 Freiburg, Germany

Education
 
1967 High school examination
1969-1972 Study of Pharmacy, University of Frankfurt
1971-1977 Study of Medicine, University of Frankfurt

Dissertations
 
1977 Dr. med. (MD) Faculty of Medicine, University of Frankfurt (Mentor Prof. Dr. H.-D. Taubert)
1981 Dr. rer. nat. (Ph. D.) Faculty of Natural Sciences (Naturwissenschaftl. Gesamtfakultät), University of Heidelberg (Mentor Prof. Dr. G. Schulz)

Habilitation
 
1983 Faculty of Theoretical Medicine, University of Heidelberg

Professional Appointments
 
1978-1984 Research Associate Department of Pharmacology at the University of Heidelberg (Group of Prof. Dr. G. Schultz)
1984-1985 Research Associate Department of Psychiatry at the University of Mainz (Director Prof. Dr. O. Benkert)
1985-1989 Associate Professor (C2) Rudolf-Buchheim-Institute of Pharmacology at the University of Gießen
1989-1991 Associate Professor (C3) Institute of Pharmacology at the University of Essen
1991-1994 Full Professor (C4) Institute of Pharmacology and Toxicology at the University of the Saarland

Present Position
 
Since 1995 Full Professor (C4)
and Director (Chair)
Department I of the Institute of Experimental and Clinical Pharmacology and Toxicology at the Albert-Ludwigs-Universität Freiburg
2003 Coordinator of the Priority Research Program 1150 (Schwerpunktprogramm 1150) of the DFG: “Signalwege zum Zytoskelett und bakterielle Pathogenität”

Sabbaticals
 
1989 Institute of Cancer Research, Chester Beatty Laboratories, London, Group of Prof. Dr. A. Hall
1998 Department of Microbiology and Molecular Genetics, Medical College Wisconsin (Milwaukee), Group of Prof. Dr. J.T. Barbieri

Honors
Julius Friedrich Cohnheim Lecture, Tel Aviv University, 1998
Member of The German Academy of Natural Scientists Leopoldina (2003)
Feldberg-Foundation Award 2005
Fellow of The American Academy of Microbiology (2008)
Member of EMBO (2008)
Phoenix Research Award (2012)
Toxicology Award der Deutschen Gesellschaft für Toxikologie (2014)

Membership in Editorial Boards (past and present)
European Journal of Pharmacology
Naunyn-Schmiedeberg’s Archives of Pharmacology
Medical Microbiology and Immunology
Toxicon
Infection and Immunity
International Journal of Medical Microbiology

Research topics
Bacterial protein toxin
- Clostridial glucosylating toxins
- Pasteurella multocida toxin
- ADP-ribosylating toxins
- Rho-GTPase activating and inhibiting toxins
- Legionella glucosyltransferases
Molecular mechanism and structure-function analysis of bacterial protein toxins
Bacterial protein toxins as pharmacological tools
Signal transduction of GTPases
Role of GTPases in neurite outgrowth and pathfinding
Signal transduction of the FceRI-receptor

Patents
 
De0019802569A1 Toxikologisch aktive Fragmente des letalen Toxins von Clostridium sordellii und deren Verwendung in Immuntoxinen
DE0019735105A1 Transportsystem zur Einbringung von Proteinen in Zielzellen mit Hilfe eines Fusionsproteins, Nucleinsäurekonstrukte kodierend für die Komponenten des Transportsystems und Arzneimittel, die Komponenten des Transportsystems umfassen
EP1452589A1 ADP-Ribosyltransferase C3cer
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