Publikationen / Publications
2019 2019 2018 2017 2016 2015 2014
Abdellatif MEA, Hipp L, Plessner M, Walther P, Knöll B (2019) Indirect visualization of endogenous nuclear actin by correlative light and electron microscopy (CLEM) using an actin-directed chromobody. Histochem Cell Biol, 152, 133-43
Abstract
Almonacid M, Al Jord A, El-Hayek S, Othmani A, Coulpier F, Lemoine S, Miyamoto K, Grosse R, Klein C, Piolot T, Mailly P, Voituriez R, Genovesio A, Verlhac MH (2019) Active Fluctuations of the Nuclear Envelope Shape the Transcriptional Dynamics in Oocytes. Dev Cell, 51, 145-57
Abstract
Bogdanovic X, Schneider S, Levanova N, Wirth C, Trillhaase C, Steinemann M, Hunte C, Aktories K, Jank T (2019) A cysteine protease-like domain enhances the cytotoxic effects of the Photorhabdus asymbiotica toxin PaTox. J Biol Chem, 294, 1035-44
Abstract
Brander S, Jank T, Hugel T (2019) AFM Imaging Suggests Receptor-Free Penetration of Lipid Bilayers by Toxins. Langmuir, 35, 365-71
Abstract
Chleilat E, Mallmann R, Spanagel R, Klugbauer N, Krieglstein K, Roussa E (2019) Spatiotemporal Role of Transforming Growth Factor Beta 2 in Developing and Mature Mouse Hindbrain Serotonergic Neurons. Front Cell Neurosci, 13, 427, 1-19
Abstract
Ebner JK, König GM, Kostenis E, Siegert P, Aktories K, Orth JH (2019) Activation of Gq signaling by Pasteurella multocida toxin inhibits the osteoblastogenic-like actions of Activin A in C2C12 myoblasts, a cell model of fibrodysplasia ossificans progressiva. Bone, 127, 592-601
Abstract
Levanova N, Mattheis C, Carson D, To KN, Jank T, Frankel G, Aktories K, Schroeder GN (2019) The Legionella effector LtpM is a new type of phosphoinositide-activated glucosyltransferase. J Biol Chem, 294, 2862-79
Abstract
Levanova N, Steinemann M, Böhmer KE, Schneider S, Belyi Y, Schlosser A, Aktories K, Jank T (2019) Characterization of the glucosyltransferase activity of Legionella pneumophila effector SetA. Naunyn Schmiedebergs Arch Pharmacol, 392, 69-79
Abstract
López-Ureña D, Orozco-Aguilar J, Chaves-Madrigal Y, Ramírez-Mata A, Villalobos-Jimenez A, Ost S, Quesada-Gómez C, Rodríguez C, Papatheodorou P, Chaves-Olarte E (2019) Toxin B Variants from Clostridium difficile Strains VPI 10463 and NAP1/027 Share Similar Substrate Profile and Cellular Intoxication Kinetics but Use Different Host Cell Entry Factors. Toxins (Basel). 11, 384, 1-15
Abstract
Mallmann RT, Moravcikova L, Ondacova K, Lacinova L, Klugbauer N (2019) Grina/TMBIM3 modulates voltage-gated Cav2.2 Ca2+ channels in a G-protein-like manner. Cell Calcium, 80, 71-8
Abstract
Mallmann R, Ondacova K, Moravcikova L, Jurkovicova-Tarabova B, Pavlovicova M, Moravcik R, Lichvarova L, Kominkova V, Klugbauer N, Lacinova L (2019) Four novel interaction partners demonstrate diverse modulatory effects on voltage-gated CaV2.2 Ca2+ channels. Pflugers Arch, 471, 861-74
Abstract
Müller CS, Bildl W, Klugbauer N, Haupt A, Fakler B, Schulte U (2019) High-Resolution Complexome Profiling by Cryoslicing BN-MS Analysis. J Vis Exp, 152, e60096, 1-10
Abstract
Ng Ang A PN, Ebner JK, Plessner M, Aktories K, Schmidt G (2019) Engineering Photorhabdus luminescens toxin complex (PTC) into a recombinant injection nanomachine. Life Sci Alliance, 2, e20190048, 1-12
Abstract
Ost GS, Ng'ang'a PN, Lang A, Aktories K (2019) Photorhabdus luminescens Tc toxin is inhibited by the protease inhibitor MG132 and activated by protease cleavage resulting in increased binding to target cells. Cell Microbiol, 21, e12978, 1-12
Abstract
Papatheodorou P, Song S, López-Ureña D, Witte A, Marques F, Ost GS, Schorch B, Chaves-Olarte E, Aktories K (2019) Cytotoxicity of Clostridium difficile toxins A and B requires an active and functional SREBP-2 pathway. FASEB J, 33, 4883-92
Abstract
Plessner M, Knerr J, Grosse R (2019) Centrosomal Actin Assembly Is Required for Proper Mitotic Spindle Formation and Chromosome Congression. iScience, 15, 274-81
Abstract
Reinartz S, Lieber S, Pesek J, Brandt DT, Asafova A, Finkernagel F, Watzer B, Nockher WA, Nist A, Stiewe T, Jansen JM, Wagner U, Konzer A, Graumann J, Grosse R, Worzfeld T, Müller-Brüsselbach S, Müller R (2019) Cell type-selective pathways and clinical associations of lysophosphatidic acid biosynthesis and signaling in the ovarian cancer microenvironment. Mol Oncol, 13, 185-201
Abstract
Schnell L, Felix I, Müller B, Sadi M, von Bank F, Papatheodorou P, Popoff MR, Aktories K, Waltenberger E, Benz R, Weichbrodt C, Fauler M, Frick M, Barth H (2019) Revisiting an old antibiotic: bacitracin neutralizes binary bacterial toxins and protects cells from intoxication. FASEB J, 33, 5755-71
Abstract
Stroukov W, Rösch A, Schwan C, Jeney A, Römer W, Thuenauer R (2019) Synchronizing Protein Traffic to the Primary Cilium. Front Genet, 10, 163, 1-10
Abstract
Tsopoulidis N, Kaw S, Laketa V, Kutscheidt S, Baarlink C, Stolp B, Grosse R, Fackler OT (2019) T cell receptor-triggered nuclear actin network formation drives CD4+ T cell effector functions. Sci Immunol, 4, eaav1987, 1-11
Abstract
Wang Y, Sherrard A, Zhao B, Melak M, Trautwein J, Kleinschnitz EM, Tsopoulidis N, Fackler OT, Schwan C, Grosse R (2019) GPCR-induced calcium transients trigger nuclear actin assembly for chromatin dynamics. Nat Commun, 10, 5271, 1-9
Abstract
Reviews, Books
Aktories K, Gierschik P, Heringdorf DMZ, Schmidt M, Schultz G, Wieland T (2019) cAMP guided his way: a life for G protein-mediated signal transduction and molecular pharmacology-tribute to Karl H. Jakobs. Naunyn Schmiedebergs Arch Pharmacol, 392, 887-911
Abstract
Caridi CP, Plessner M, Grosse R, Chiolo I (2019) Nuclear actin filaments in DNA repair dynamics. Nat Cell Biol, 21, 1068-77
Abstract
Plessner M, Grosse R (2019) Dynamizing nuclear actin filaments. Curr Opin Cell Biol, 56, 1-6
Abstract
2018 2019 2018 2017 2016 2015 2014
Brink T, Leiss V, Siegert P, Jehle D, Ebner JK, Schwan C, Shymanets A, Wiese S, Nürnberg B, Hensel M, Aktories K, Orth JHC (2018) Salmonella Typhimurium effector SseI inhibits chemotaxis and increases host cell survival by deamidation of heterotrimeric Gi proteins. PLoS Pathog, 14, e1007248, 1-23
Abstract
Haun F, Neumann S, Peintner L, Wieland K, Habicht J, Schwan C, Østevold K, Koczorowska MM, Biniossek M, Kist M, Busch H, Boerries M, Davis RJ, Maurer U, Schilling O, Aktories K, Borner C (2018) Identification of a novel anoikis signalling pathway using the fungal virulence factor gliotoxin. Nat Commun, 9, 3524, 1-14
Abstract
Heni H, Ebner JK, Schmidt G, Aktories K, Orth JHC (2018) Involvement of Osteocytes in the Action of Pasteurella multocida Toxin. Toxins (Basel), 10, 328, 1-15
Abstract
Normann C, Frase S, Haug V, von Wolff G, Clark K, Münzer P, Dorner A, Scholliers J, Horn M, Vo Van T, Seifert G, Serchov T, Biber K, Nissen C, Klugbauer N, Bischofberger J (2018) Antidepressants Rescue Stress-Induced Disruption of Synaptic Plasticity via Serotonin Transporter-Independent Inhibition of L-Type Calcium Channels. Biol Psychiatry, 84, 55-64
Abstract
Schorch B, Heni H, Zahaf NI, Brummer T, Mione M, Schmidt G, Papatheodorou P, Aktories K (2018) Targeting oncogenic Ras by the Clostridium perfringens toxin TpeL. Oncotarget, 9, 16489-500
Abstract
Steinemann M, Schlosser A, Jank T, Aktories K (2018) The chaperonin TRiC/CCT is essential for the action of bacterial glycosylating protein toxins like Clostridium difficile toxins A and B. Proc Natl Acad Sci U S A, 115, 9580-5
Abstract
Reviews, Books
Aktories K, Papatheodorou P, Schwan C (2018) Binary Clostridium difficile toxin (CDT) - A virulence factor disturbing the cytoskeleton. Anaerobe, 53, 21-9
Abstract
Papatheodorou P, Barth H, Minton N, Aktories K (2018) Cellular Uptake and Mode-of-Action of Clostridium difficile Toxins. Adv Exp Med Biol, 1050, 77-96
Abstract
Schmidt G (2018) Methods to Study Rho GTPases Using Bacterial Toxins. Methods Mol Biol, 1821, 141-54
Abstract
2017 2019 2018 2017 2016 2015 2014
Baarlink C, Plessner M, Sherrard A, Morita K, Misu S, Virant D, Kleinschnitz EM, Harniman R, Alibhai D, Baumeister S, Miyamoto K, Endesfelder U, Kaidi A, Grosse R (2017) A transient pool of nuclear F-actin at mitotic exit controls chromatin organization. Nat Cell Biol, 19, 1389-99
Abstract
Carle S, Brink T, Orth JH, Aktories K, Barth H (2017) Auranofin Inhibits the Enzyme Activity of Pasteurella multocida Toxin PMT in Human Cells and Protects Cells from Intoxication. Toxins (Basel), 9, 32, 1-8
Abstract
Castonguay J, Orth JHC, Müller T, Sleman F, Grimm C, Wahl-Schott C, Biel M, Mallmann RT, Bildl W, Schulte U, Klugbauer N (2017) The two-pore channel TPC1 is required for efficient protein processing through early and recycling endosomes. Sci Rep, 7, 10038, 1-15
Abstract
Czulkies BA, Mastroianni J, Lutz L, Lang S, Schwan C, Schmidt G, Lassmann S, Zeiser R, Aktories K, Papatheodorou P (2017) Loss of LSR affects epithelial barrier integrity and tumor xenograft growth of CaCo-2 cells. Oncotarget, 8, 37009-22
Abstract
Ernst K, Schmid J, Beck M, Hägele M, Hohwieler M, Hauff P, Ückert AK, Anastasia A, Fauler M, Jank T, Aktories K, Popoff MR, Schiene-Fischer C, Kleger A, Müller M, Frick M, Barth H (2017) Hsp70 facilitates trans-membrane transport of bacterial ADP-ribosylating toxins into the cytosol of mammalian cells. Sci Rep, 7, 2724, 1-16
Abstract
Jank T, Belyi Y, Wirth C, Rospert S, Hu Z, Dengjel J, Tzivelekidis T, Andersen GR, Hunte C, Schlosser A, Aktories K (2017) Protein glutaminylation is a yeast-specific posttranslational modification of elongation factor 1A. J Biol Chem, 292, 16014-23
Abstract
Harterink M, da Silva ME, Will L, Turan J, Ibrahim A, Lang AE, van Battum EY, Pasterkamp RJ, Kapitein LC, Kudryashov D, Barres BA, Hoogenraad CC, Zuchero JB (2017) DeActs: genetically encoded tools for perturbing the actin cytoskeleton in single cells. Nat Methods, 14, 479-82
Abstract
Hinojosa LS, Holst M, Baarlink C, Grosse R (2017) MRTF transcription and Ezrin-dependent plasma membrane blebbing are required for entotic invasion. J Cell Biol, 216, 3087-95
Abstract
Lang AE, Qu Z, Schwan C, Silvan U, Unger A, Schoenenberger CA, Aktories K, Mannherz HG (2017) Actin ADP-ribosylation at Threonine148 by Photorhabdus luminescens toxin TccC3 induces aggregation of intracellular F-actin. Cell Microbiol, 19, 1-14
Abstract
Lang S, Busch H, Boerries M, Brummer T, Timme S, Lassmann S, Aktories K, Schmidt G (2017) Specific role of RhoC in tumor invasion and metastasis. Oncotarget, 8, 87364-78
Abstract
Østevold K, Meléndez AV, Lehmann F, Schmidt G, Aktories K, Schwan C (2017) Septin remodeling is essential for the formation of cell membrane protrusions (microtentacles) in detached tumor cells. Oncotarget, 8, 76686-98
Abstract
Reppin F, Cochet S, El Nemer W, Fritz G, Schmidt G (2017) High Affinity Binding of Escherichia coli Cytotoxic Necrotizing Factor 1 (CNF1) to Lu/BCAM Adhesion Glycoprotein. Toxins (Basel), 10, 3, 1-14
Abstract
Schuster M, Schnell L, Feigl P, Birkhofer C, Mohr K, Roeder M, Carle S, Langer S, Tippel F, Buchner J, Fischer G, Hausch F, Frick M, Schwan C, Aktories K, Schiene-Fischer C, Barth H (2017) The Hsp90 machinery facilitates the transport of diphtheria toxin into human cells. Sci Rep, 7, 613, 1-14
Abstract
Zahaf NI, Lang AE, Kaiser L, Fichter CD, Lassmann S, McCluskey A, Augspach A, Aktories K, Schmidt G (2017) Targeted delivery of an ADP-ribosylating bacterial toxin into cancer cells. Sci Rep, 7, 41252, 1-10
Abstract
Reviews, Books
Aktories K, Schwan C, Lang AE (2017) ADP-Ribosylation and Cross-Linking of Actin by Bacterial Protein Toxins. Handb Exp Pharmacol, 235, 179-206
Abstract
Aktories K, Schwan C, Jank T (2017) Clostridium difficile Toxin Biology. Annu Rev Microbiol, 71, 281-307
Abstract
Klugbauer N (2017) New clues on Sidt2 being a cation conducting protein in lysosomal membranes. FEBS Lett, 591, 3-4
Abstract
Papatheodorou P, Aktories K (2017) Receptor-Binding and Uptake of Binary Actin-ADP-Ribosylating Toxins. Curr Top Microbiol Immunol, 406, 119-33
Abstract
Schwan C, Aktories K (2017) Formation of Nanotube-Like Protrusions, Regulation of Septin Organization and Re-guidance of Vesicle Traffic by Depolymerization of the Actin Cytoskeleton Induced by Binary Bacterial Protein Toxins. Curr Top Microbiol Immunol, 399, 35-51
Abstract
Sheets J, Aktories K (2017) Insecticidal Toxin Complexes from Photorhabdus luminescens. Curr Top Microbiol Immunol, 402, 3-23
Abstract
Zahaf NI, Schmidt G (2017) Bacterial Toxins for Cancer Therapy. Toxins (Basel), 9, 236, 1-11
Abstract
2016 2019 2018 2017 2016 2015 2014
Cowardin CA, Buonomo EL, Saleh MM, Wilson MG, Burgess SL, Kuehne SA, Schwan C, Eichhoff AM, Koch-Nolte F, Lyras D, Aktories K, Minton NP, Petri WA Jr (2016) The binary toxin CDT enhances Clostridium difficile virulence by suppressing protective colonic eosinophilia. Nat Microbiol, 1, 16108
Abstract
Eisenhardt AE, Sprenger A, Röring M, Herr R, Weinberg F, Köhler M, Braun S, Orth J, Diedrich B, Lanner U, Tscherwinski N, Schuster S, Dumaz N, Schmidt E, Baumeister R, Schlosser A, Dengjel J, Brummer T (2016) Phospho-proteomic analyses of B-Raf protein complexes reveal new regulatory principles. Oncotarget, 7, 26628-52
Abstract
Nölke T, Schwan C, Lehmann F, Østevold K, Pertz O, Aktories K (2016) Septins guide microtubule protrusions induced by actin-depolymerizing toxins like Clostridium difficile transferase (CDT). Proc Natl Acad Sci U.S.A, 113, 7870-5
Abstract
Schnell L, Mittler AK, Sadi M, Popoff MR, Schwan C, Aktories K, Mattarei A, Tehran DA, Montecucco C, Barth H (2016) EGA Protects Mammalian Cells from Clostridium difficile CDT, Clostridium perfringens Iota Toxin and Clostridium botulinum C2 Toxin. Toxins (Basel), 8, 101, 1-14
Abstract
Vannini E, Olimpico F, Middei S, Ammassari-Teule M, de Graaf EL, McDonnell L, Schmidt G, Fabbri A, Fiorentini C, Baroncelli L, Costa M, Caleo M (2016) Electrophysiology of glioma: a Rho GTPase-activating protein reduces tumor growth and spares neuron structure and function. Neuro Oncol, 18, 1634-43
Abstract
Wardecki T, Werner P, Thomas M, Templin MF, Schmidt G, Brandner J .M, Merfort I (2016) Influence of Birch Bark Triterpenes on Keratinocytes and Fibroblasts from Diabetic and Nondiabetic Donors. J Nat Prod, 79, 1112-23
Abstract
Reviews, Books
Jank T, Lang AE, Aktories K (2016) Rho-modifying bacterial protein toxins from Photorhabdus species. Toxicon, 116, 17-22
Abstract
Papatheodorou P, Aktories K (2016) Preface for Anaerobe - Special issue on Clostpath9. Anaerobe, 41, 1
Abstract
2015 2019 2018 2017 2016 2015 2014
Belyy A, Tabakova I, Lang AE, Jank T, Belyi Y, Aktories K (2015) Roles of Asp179 and Glu270 in ADP-Ribosylation of Actin by Clostridium perfringens Iota Toxin. PLoS One, 10, e0145708, 1-15
Abstract
Dille S, Kleinschnitz EM, Kontchou CW, Nölke T, Häcker G (2015) In contrast to Chlamydia trachomatis, Waddlia chondrophila grows in human cells without inhibiting apoptosis, fragmenting the Golgi apparatus, or diverting post-Golgi sphingomyelin transport. Infect Immun, 83, 3268-80
Abstract
Ernst K, Langer S, Kaiser E, Osseforth C, Michaelis J, Popoff MR, Schwan C, Aktories K, Kahlert V, Malesevic M, Schiene-Fischer C, Barth H (2015) Cyclophilin-Facilitated Membrane Translocation as Pharmacological Target to Prevent Intoxication of Mammalian Cells by Binary Clostridial Actin ADP-Ribosylated Toxins. J Mol Biol, 427, 1224-38
Abstract
Grikscheit K, Frank T, Wang Y, Grosse R (2015) Junctional actin assembly is mediated by Formin-like 2 downstream of Rac1. J Cell Biol, 209, 367-76
Abstract
Hemmasi S, Czulkies BA, Schorch B, Veit A, Aktories K, Papatheodorou P (2015) Interaction of the Clostridium difficile Binary Toxin CDT and its Host Cell Receptor LSR. J Biol Chem, 290, 14031-44
Abstract
Jank T, Eckerle S, Steinemann M, Trillhaase C, Schimpl M, Wiese S, van Aalten DM, Driever W, Aktories K (2015) Tyrosine glycosylation of Rho by Yersinia toxin impairs blastomere cell behaviour in zebrafish embryos. Nat Commun, 6, 7807, 1-16
Abstract
Jank T, Trillhaase C, Brozda N, Steinemann M, Schwan C, Süss R, Aktories K (2015) Intracellular plasma membrane guidance of Photorhabdus asymbiotica toxin is crucial for cell toxicity. FASEB J, 29, 2789-802
Abstract
Mayer SC, Gilsbach R, Preissl S, Monroy Ordonez EB, Schnick T, Beetz N, Lother A, Rommel C, Ihle H, Bugger H, Rühle F, Schrepper A, Schwarzer M, Heilmann C, Bönisch U, Gupta SK, Wilpert J, Kretz O, von Elverfeldt D, Orth J, Aktories K, Beyersdorf F, Bode C, Stiller B, Krüger M, Thum T, Doenst T, Stoll M, Hein L (2015) Adrenergic Repression of the Epigenetic Reader MeCP2 Facilitates Cardiac Adaptation in Chronic Heart Failure. Circ Res, 117, 622-33
Abstract
Pfaumann V, Lang AE, Schwan C, Schmidt G, Aktories K (2015) The actin and Rho-modifying toxins PTC3 and PTC5 of Photorhabdus luminescens: Enzyme characterization and induction of MAL/SRF-dependent transcription. Cell Microbiol, 17, 579-94
Abstract
Plessner M, Melak M, Chinchilla P, Baarlink C, Grosse R (2015) Nuclear F-actin formation and reorganization upon cell spreading. J Biol Chem, 290, 11209-16
Abstract
Sakurai Y, Kolokoltsov AA, Chen CC, Tidwell MW, Bauta WE, Klugbauer N, Grimm C, Wahl-Schott C, Biel M, Davey RA (2015) Ebola virus. Two-pore channels control Ebola virus host cell entry and are drug targets for disease treatment. Science, 347, 995-8
Abstract
Stankiewicz TR, Ramaswami SA, Bouchard RJ, Aktories K, Linseman DA (2015) Neuronal apoptosis induced by selective inhibition of Rac GTPase versus global suppression of Rho family GTPases is mediated by alterations in distinct mitogen-activated protein kinase signaling cascades. J Biol Chem, 290, 9363-76
Abstract
Unger M, Eichhoff AM, Schumacher L, Strysio M, Menzel S, Schwan C, Alzogaray V, Zylberman V, Seman M, Brandner J, Rohde H, Zhu K, Haag F, Mittrücker HW, Goldbaum F, Aktories K, Koch-Nolte F (2015) Selection of Nanobodies that Block the Enzymatic and Cytotoxic Activities of the Binary Clostridium Difficile Toxin CDT. Sci Rep, 5, 7850, 1-10
Abstract
Wang Y, Arjonen A, Pouwels J, Ta H, Pausch P, Bange G, Engel U, Pan X, Fackler OT, Ivaska J, Grosse R (2015) Formin-like 2 Promotes β1-Integrin Trafficking and Invasive Motility Downstream of PKCα. Dev Cell, 34, 475-83
Abstract
Weise M, Vettel C, Spiger K, Gilsbach R, Hein L, Lorenz K, Wieland T, Aktories K, Orth JH (2015) A systemic Pasteurella multocida toxin aggravates cardiac hypertrophy and fibrosis in mice. Cell Microbiol, 17, 1320-31
Abstract
Reviews, Books
Aktories K, Schmidt G, Lang AE (2015) Photorhabdus luminescens Toxins TccC3 and TccC5: Insecticidal ADP-Ribosyltransferases that Modify Threonine and Glutamine. Curr Top Microbiol Immunol, 384, 53-67
Abstract
Aktories K (2015) Rho-modifying bacterial protein toxins. Pathog Dis, 73, ftv091, 1-10
Abstract
Jank T, Belyi Y, Aktories K (2015) Bacterial glycosyltransferase toxins. Cell Microbiol, 17, 1752-65
Abstract
Schmidt G, Papatheodorou P, Aktories K (2015) Novel receptors for bacterial protein toxins. Curr Opin Microbiol, 23, 55-61
Abstract
Wilson BA, Bergmann S, Ho M, Orth JHC (2015) Pasteurella multocida toxin. In: The Comprehensive Sourcebook of Bacterial Protein Toxins (Fourth Edition). Alouf J, Ladant D, Popoff MR, (eds.), Elsevier Ltd, 463-98
Abstract
2014 2019 2018 2017 2016 2015 2014
Arndt L, Castonguay J, Arlt E, Meyer D, Hassan S, Borth H, Zierler S, Wennemuth G, Breit A, Biel M, Wahl-Schott C, Gudermann T, Klugbauer N, Boekhoff I (2014) NAADP and the two-pore channel protein 1 participate in the acrosome reaction in mammalian spermatozoa. Mol Biol Cell, 25, 948-64
Abstract
Dille S, Herbst K, Volceanov L, Nölke T, Kretz O, Häcker G (2014) Golgi fragmentation and sphingomyelin transport to Chlamydia trachomatis during penicillin-induced persistence do not depend on the cytosolic presence of the chlamydial protease CPAF. PLoS One, 9, e103220, 1-10
Abstract
Ebeling S, Naumann K, Pollok S, Wardecki T, Vidal-Y-Sy S, Nascimento JM, Boerries M, Schmidt G, Brandner JM, Merfort I (2014) From a traditional medicinal plant to a rational drug: understanding the clinically proven wound healing efficacy of birch bark extract. PLoS One, 9, e86147, 1-18
Abstract
Fichter CD, Gudernatsch V, Przypadlo CM, Follo M, Schmidt G, Werner M, Lassmann S (2014) ErbB targeting inhibitors repress cell migration of esophageal squamous cell carcinoma and adenocarcinoma cells by distinct signaling pathways. J Mol Med, 92, 1209-23
Abstract
Grimm C, Holdt LM, Chen CC, Hassan S, Müller C, Jörs S, Cuny H, Kissing S, Schröder B, Butz E, Northoff B, Castonguay J, Luber CA, Moser M, Spahn S, Lüllmann-Rauch R, Fendel C, Klugbauer N, Griesbeck O, Haas A, Mann M, Bracher F, Teupser D, Saftig P, Biel M, Wahl-Schott C (2014) High susceptibility to fatty liver disease in two-pore channel 2-deficient mice. Nat Commun, 5, 4699, 1-13
Abstract
Hildebrand D, Bode KA, Rieß D, Cerny D, Waldhuber A, Römmler F, Strack J, Korten S, Orth JH, Miethke T, Heeg K, Kubatzky KF (2014) Granzyme A Produces Bioactive IL-1β through a Nonapoptotic Inflammasome-Independent Pathway. Cell Rep, 9, 910-17
Abstract
Lang AE, Ernst K, Lee H, Papatheodorou P, Schwan C, Barth H, Aktories K (2014) The chaperone Hsp90 and PPIases of the cyclophilin and FKBP families facilitate membrane translocation of Photorhabdus luminescens ADP-ribosyltransferases. Cell Microbiol, 16, 490-503
Abstract
Meusch D, Gatsogiannis C, Efremov RG, Lang AE, Hofnagel O, Vetter IR, Aktories K, Raunser S (2014) Mechanism of Tc toxin action revealed in molecular detail. Nature, 508, 61-5
Abstract
Piteau M, Papatheodorou P, Schwan C, Schlosser A, Aktories K, Schmidt G (2014) Lu/BCAM adhesion glycoprotein is a receptor for Escherichia coli Cytotoxic Necrotizing Factor 1 (CNF1). PLoS Pathog, 10, e1003884, 1-12
Abstract
Purvanov V, Holst M, Khan J, Baarlink C, Grosse R (2014) G-protein-coupled receptor signaling and polarized actin dynamics drive cell-in-cell invasion. Elife, 3, e02786, 1-11
Abstract
Roeder M, Nestorovich EM, Karginov VA, Schwan C, Aktories K, Barth H (2014) Tailored cyclodextrin pore blocker protects mammalian cells from clostridium difficile binary toxin CDT. Toxins (Basel), 6, 2097-114
Abstract
Schorch B, Song S, van Diemen FR, Bock HH, May P, Herz J, Brummelkamp TR, Papatheodorou P, Aktories K (2014) LRP1 is a receptor for Clostridium perfringens TpeL toxin indicating a two-receptor model of clostridial glycosylating toxins. Proc Natl Acad Sci U.S.A, 111, 6431-6
Abstract
Schwan C, Kruppke AS, Nölke T, Schumacher L, Koch-Nolte F, Kudryashev M, Stahlberg H, Aktories K (2014) Clostridium difficile toxin CDT hijacks microtubule organization and reroutes vesicle traffic to increase pathogen adherence. Proc Natl Acad Sci U.S.A, 111, 2313-8
Abstract
Strack J, Heni H, Gilsbach R, Hein L, Aktories K, Orth JH (2014) Noncanonical G-Protein-Dependent Modulation of Osteoclast Differentiation and Bone Resorption Mediated by Pasteurella multocida Toxin. MBio, 5, e02190-14, 1-9
Abstract
Volceanov L, Herbst K, Biniossek M, Schilling O, Haller D, Nölke T, Subbarayal P, Rudel T, Zieger B, Häcker G (2014) Septins arrange F-actin-containing fibers on the Chlamydia trachomatis inclusion and are required for normal release of the inclusion by extrusion. MBio, 5, e01802-14, 1-12
Abstract
Young JC, Clements A, Lang AE, Garnett JA, Munera D, Arbeloa A, Pearson J, Hartland EL, Matthews SJ, Mousnier A, Barry DJ, Way M, Schlosser A, Aktories K, Frankel G (2014) The Escherichia coli effector EspJ blocks Src kinase activity via amidation and ADP ribosylation. Nat Commun, 5, 5887, 1-10
Abstract
Reviews, Books
Aktories K, Schmidt G (2014) Bacterial Protein Toxins Acting on Small GTPases. In: Ras Superfamily Small G Proteins: Biology and Mechanisms 1. Wittinghofer, A (ed.), Springer Vienna, 64-97
Abstract
Bergmann S, Orth JH (2014) Die Wirkung von Pasteurella multocida-Toxin auf Knochen. BIOspektrum 20, 275-7
Abstract
Gerding DN, Johnson S, Rupnik M, Aktories K (2014) Clostridium difficile binary toxin CDT: Mechanism, epidemiology, and potential clinical importance. Gut Microbes, 5, 15-27
Abstract
Simon NC, Aktories K, Barbieri JT (2014) Novel bacterial ADP-ribosylating toxins: structure and function. Nat Rev Microbiol, 12, 599-611
Abstract
03. Februar 2020